The most common sign of AGU is the lack or delay of speech. In addition, other signs and symptoms that become apparent in AGU children throughout the elementary school-age years include:

• Speech delay: support needed for missing words or letters
• Sleep disturbance
• Inability to learn shapes or trace figures
• Inability to follow simple directions and trouble managing daily tasks
• Thickening of facial features: widely-spaced eyes, small ears, full lips, large tongue, broad nose
• Upper respiratory infections, specifically ear infections
• Hernias around the belly button or in the groin area
• Gastrointestinal symptoms including diarrhea or constipation
• Orthopedic challenges, which may require surgery, including rolling instep, toe walking, knock knees, or spastic running