The most common sign of AGU is the lack or delay of speech. In addition, other signs and symptoms that become apparent in AGU children throughout the elementary school-age years include:
- Speech delay: support needed for missing words or letters
- Sleep disturbance
- Inability to learn shapes or trace figures
- Inability to follow simple directions and trouble managing daily tasks
- Thickening of facial features: widely-spaced eyes, small ears, full lips, large tongue, broad nose
- Upper respiratory infections, specifically ear infections
- Hernias around the belly button or in the groin area
- Gastrointestinal symptoms including diarrhea or constipation
- Orthopedic challenges, which may require surgery, including rolling instep, toe walking, knock knees, or spastic running