Adolescent Years

As the disease continues to progress through the adolescent years, other signs and symptoms may become apparent:

  • Intellectual disability will progressively worsen
  • Sleep disturbance
  • Anxiety, restlessness, and inability to understand the concept of time
  • Emotional, behavioral, and psychiatric issues can arise
  • Dental complications such as tooth decay, large tongue, and enlarged tonsils
  • Progressive thickening of facial features: widely-spaced eyes, small ears, full lips, large tongue, broad nose
  • Gastrointestinal symptoms including diarrhea or constipation
  • Gait (walking) disturbance