As the disease continues to progress through the adolescent years, other signs and symptoms may become apparent:
- Intellectual disability will progressively worsen
- Sleep disturbance
- Anxiety, restlessness, and inability to understand the concept of time
- Emotional, behavioral, and psychiatric issues can arise
- Dental complications such as tooth decay, large tongue, and enlarged tonsils
- Progressive thickening of facial features: widely-spaced eyes, small ears, full lips, large tongue, broad nose
- Gastrointestinal symptoms including diarrhea or constipation
- Gait (walking) disturbance